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Medicine

Guide to resources for medical research

Primary Sources

Once you have done some preliminary research using secondary sources and have fine-tuned your research question, it's time to explore the primary literature. In the sciences, primary sources typically report on original research studies and take the form of scholarly articles published in peer-reviewed journals (they are also sometimes referred to as "papers"). 

Use the box below to explore different places to locate primary sources. 

Searching the Medical Literature: PICO

It's important when searching the medical literature to formulate specific, answerable clinical or research questions. The PICO mnemonic can be a useful way to break your topic into searchable components:

P = Patient (population or problem): Who or what are you studying?
I = Intervention: What is the diagnostic test, treatment or therapy? Or what are the prognostic factors or exposures?
C = Comparison: What are you measuring this intervention against?
O = Outcome(s): What are you trying to accomplish, measure, improve or effect?

  • For example: “For people with high-risk pregnancies (P), does aspirin (I) or progesterone (C) better prevent premature birth (O)?"
  • If you are asking a question about etiology or harm, swap out the "I" for an "E." E would stand for the exposure a patient experienced.

Once you have your PICO question, you can break down each concept into a search strategy. For example:

high-risk pregnancy (aspirin OR progesterone) premature birth

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